Switching on to potassium channels
نویسندگان
چکیده
منابع مشابه
Potassium channels.
The atomic structures of K+ channels have added a new dimension to our understanding of K+ channel function. I will briefly review how structures have influenced our views on ion conduction, gating of the pore, and voltage sensing.
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Objective Purkinje neuron dysfunction is associated with cerebellar ataxia. In a mouse model of spinocerebellar ataxia type 1 (SCA1), reduced potassium channel function contributes to altered membrane excitability resulting in impaired Purkinje neuron spiking. We sought to determine the relationship between altered membrane excitability and motor dysfunction in SCA1 mice. Methods Patch-clamp ...
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Department of Biology, Technische Universität-Darmstadt, Schnittspahnstrasse 3, 64287 Darmstadt, Germany (G.T.); Department of Biosciences, University of Milan, Via Celoria 26, 20133 Milan Italy (A.M.); Information Genomique and Structurale, Unité Mixte de Recherche 7256, Centre National de la Recherche Scientifique, Aix-Marseille Universite, FR–13288 Marseille, France (G.B.); and Department of...
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Mitochondrial potassium channels, such as ATP-regulated or large conductance Ca2+ -activated and voltage gated channels were implicated in cytoprotective phenomenon in different tissues. Basic effects of these channels activity include changes in mitochondrial matrix volume, mitochondrial respiration and membrane potential, and generation of reactive oxygen species. In this paper, we describe t...
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The present study reports a microwave-assisted method for the synthesis of twelve novel tricyclic 1,4-dihydropyridine derivatives in which dimethyl-substituted cyclohexane and / or tetrahydrothiophene rings are fused to the DHP ring. The structures of the compounds were confirmed by spectral methods and elemental analysis. The potassium channel opening effects of the compounds were determined o...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2005
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn1759